Spurs struggled to the runners-up spot in a group containing Barcelona and Inter Milan, but Mauricio Pochettino's team have recorded three successive victories in all competitions.
Ahead of this week's meeting, Sports Mole assesses how the South Korean has fared in his previous outings against Dortmund.
Son represented Hamburg and Bayer Leverkusen before his switch to Spurs, and it means that the attacker has played against Dortmund on 10 different occasions.
Six of those matches came in Germany's top flight, with Son netting a total of five goals from those outings which includes back-to-back doubles for Hamburg during the 2012-13 campaign.
Four wins and a draw came from six contests in the Bundesliga, but Son was on the losing side in both matches when Spurs played Dortmund in the last 16 of the Europa League in 2016.
However, it was a different story during the closing months of 2017. Spurs recorded back-to-back wins in the Champions League with Son netting in both of those encounters.
Son heads into this week's clash having netted in each of his last three appearances against Dortmund.