The Ligue 1 giants have dominated domestically in recent years and sit 10 points clear at the top of the table this time around too, but success in the Champions League has so far eluded them.
Here, Sports Mole looks at how Thomas Tuchel could set the visitors up at Old Trafford.
PSG are likely to be without two of their vaunted front three for the trip to Old Trafford, with Neymar definitely out with a foot injury and Edinson Cavani a major doubt after being forced off against Bordeaux on Saturday.
Kylian Mbappe is fit and firing, though, and will likely lead the line alone with Tuchel being forced into a reshuffle due to the injury concerns.
Former Manchester United attacker Angel Di Maria is expected to start as a result, while Christopher Nkunku and Julian Draxler could provide further attacking support should Tuchel opt for a 4-2-3-1 system ahead of a 4-3-3.
Tuchel has been using Dani Alves in midfield in recent weeks, but Marquinhos has more experience in that position and so may be preferred for this match, leaving Alves to compete for a right-back slot with Thilo Kehrer in the absence of the injured Thomas Meunier.