Chelsea are currently fourth in the Premier League table, six points ahead of eighth-placed United, who have only picked up one league success since the turn of the year.
Nicholas has said that Frank Lampard's side will need to 'get the basics right' on Monday evening if they are to triumph but has predicted a 2-1 success for the capital outfit.
"Manchester United will have got some of their players fit during the break. They were excellent when they went to Manchester City twice, but they are showing no consistency. This is why people are still backing, and hoping for, Mauricio Pochettino to come in," Nicholas told Sky Sports News.
"I do think Chelsea will have enough, but they will need to focus on getting their style right and doing the basics effectively."
United have already beaten the Blues twice this season, following a 4-0 success on the opening weekend of the 2019-20 Premier League season with a 2-1 victory at Stamford Bridge in the EFL Cup.
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Charlie Nicholas expects Manchester United to lose at Chelsea
ODION IGHALO has his beloved sister Mary’s name inscribed on his football boots.
It is also etched into a white T-shirt he will wear under the Manchester United jersey he will proudly don for the first time at Chelsea on Monday.
But United’s new loan signing admits he is struggling to come to terms with her sudden death, breaking down in tears when he is on his own.
Speaking for the first time about the December tragedy, Ighalo revealed: “I feel very emotional because it has not really struck me that my sister is gone forever and I am never going to see her again.
"Sometimes when I am alone and I just remember her, I have one sharp pain in my heart.
Mary was like a mother to all of us. Even when I was young she would look after me.
"My twin sister, Akhere, will call me, crying, saying she misses her and, sometimes when I am alone, I cry too.
"It is a very painful loss but I am trying to be strong as a man."
The Nigerian striker, 30, posted a poignant picture of himself with Mary on Instagram, announcing her shock death, accompanied by the words “RIP sister” together with a broken heart emoji.
Married Mary Atole collapsed at her home in Canada on the morning of December 12, just as she was getting her children ready for school. She was only 43.
“Achieving it makes me even more grateful and to become the first Nigerian to play for United is an honour I will cherish for the rest of my life.”
After the loan transfer was agreed, Ighalo flew from Shanghai to Dubai then on to Manchester, as his new team-mates departed for their warm weather training camp in Spain.
Since then, Ighalo has been working with a personal trainer at the Great Britain taekwondo centre near his Lowry Hotel base in Manchester.
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But he will join up with his new team-mates tomorrow and is expected to play some part in Monday’s clash at Chelsea.
Ighalo added: “I want to thank the fans for all the messages of support since the day I arrived in Manchester.
“This is the biggest club in the world. I know it’s a new team and a big challenge, but I am going to give my best in every game to make sure we accomplish what we want. God bless all the United fans.”
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