The Red Devils beat the La Liga outfit by a comfortable 4-1 scoreline last week and they should be favourites to reach the quarter-final.

Ahead of the second leg, they have received a triple boost with Anthony Martial , Victor Lindelof and Marcel Sabitzer involved in team training.

Martial has not played since the first week of February with a hip concern but he should make his comeback against Betis away from home.

Meanwhile, Lindelof has overcome his minor illness while Sabitzer has recovered from an undefined injury to make the trip to Seville.

Erik ten Hag has resisted making wholesale changes over the past few months and he is likely to pick a strong line-up once more.

Casemiro is one of those expected to start, considering he is suspended for the next four domestic games after his red card on Sunday.

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