At the start of March, Iniesta sustained a hamstring injury during the 1-0 victory over Atletico Madrid and it has resulted in the playmaker spending a period on the sidelines.
At a press conference, the 54-year-old told reporters: "When a game like this, the player is always more willing to play. Is the risk too excessive or not? We will see."
The tie is currently locked at 1-1 after a draw in the first leg at Stamford Bridge last month.